Categories: Science

Mice study unravels new insights to boost treatment of liver fibrosis


LONDON: A study on genes of two different mouse models with liver disease has helped a team of Austrian researchers to better understand liver scarring and to develop more effective treatments for the disease.
Scarring, also known as fibrosis, occurs when liver cells are replaced by fibrous tissue. The largest internal organ then hardens and becomes unable to perform its functions, leading to liver failure.
To better understand the scarring process, the team from the Medical University of Vienna and the Center for Molecular Medicine (CeMM) examined gene activity in two different mouse models.
Their results, published in the journal iScience, revealed dynamic molecular processes that can help reverse liver fibrosis.
The team found that “some genes were upregulated during the progression of the disease and downregulated during regression”.
Some also showed changes persistently during the regression phase, pointing out the lasting effects of liver damage.
Linking the genetic information to the disease indicators, the team identified the genetic drivers of the disease. They found four “hub” genes with links to fibrosis, portal venous pressure, histological data, and blood markers. The “hub” genes can also be developed into clinically relevant biomarkers, the researchers said.
The results were also tested and confirmed in a study on patients with liver diseases.

function loadGtagEvents(isGoogleCampaignActive) { if (!isGoogleCampaignActive) { return; } var id = document.getElementById('toi-plus-google-campaign'); if (id) { return; } (function(f, b, e, v, n, t, s) { t = b.createElement(e); t.async = !0; t.defer = !0; t.src = v; t.id = 'toi-plus-google-campaign'; s = b.getElementsByTagName(e)[0]; s.parentNode.insertBefore(t, s); })(f, b, e, 'https://www.googletagmanager.com/gtag/js?id=AW-877820074', n, t, s); };

function loadSurvicateJs(allowedSurvicateSections = []){ const section = window.location.pathname.split('/')[1] const isHomePageAllowed = window.location.pathname === '/' && allowedSurvicateSections.includes('homepage')

if(allowedSurvicateSections.includes(section) || isHomePageAllowed){ (function(w) { var s = document.createElement('script'); s.src="https://survey.survicate.com/workspaces/0be6ae9845d14a7c8ff08a7a00bd9b21/web_surveys.js"; s.async = true; var e = document.getElementsByTagName('script')[0]; e.parentNode.insertBefore(s, e); })(window); }

}

window.TimesApps = window.TimesApps || {}; var TimesApps = window.TimesApps; TimesApps.toiPlusEvents = function(config) { var isConfigAvailable = "toiplus_site_settings" in f && "isFBCampaignActive" in f.toiplus_site_settings && "isGoogleCampaignActive" in f.toiplus_site_settings; var isPrimeUser = window.isPrime; if (isConfigAvailable && !isPrimeUser) { loadGtagEvents(f.toiplus_site_settings.isGoogleCampaignActive); loadFBEvents(f.toiplus_site_settings.isFBCampaignActive); loadSurvicateJs(f.toiplus_site_settings.allowedSurvicateSections); } else { var JarvisUrl="https://jarvis.indiatimes.com/v1/feeds/toi_plus/site_settings/643526e21443833f0c454615?db_env=published"; window.getFromClient(JarvisUrl, function(config){ if (config) { loadGtagEvents(config?.isGoogleCampaignActive); loadFBEvents(config?.isFBCampaignActive); loadSurvicateJs(config?.allowedSurvicateSections); } }) } }; })( window, document, 'script', );

Source link

jaghit

Share
Published by
jaghit

Recent Posts

'मुख्यमंत्री कोविड-19 बाल सेवा योजना' के लिए नहीं है बजट? अब मंत्री नरेंद्र पटेल ने किया ये दावा

<p style="text-align: justify;"><strong>Madhya Pradesh News Today:</strong> भारत सहित पूरी दुनिया ने 3 साल वैश्विक महामारी…

2 months ago

Inside Hina Khan’s Pre-Birthday Celebrations With Rocky Jaiswal And Mother In Goa

Hina Khan’s birthday is on October 2. (Photo Credits: Instagram)From a stunning view of her…

2 months ago

Swiggy IPO Gets Sebi Approval: All You Need to Know About Rs 11,000-Crore Issue

Food and grocery delivery major Swiggy has received markets regulator Sebi’s clearance to launch its…

2 months ago

‘Imprints of Make in India visible everywhere’: PM Modi lauds 10 years of flagship initiative | India News

NEW DELHI: Prime Minister Narendra Modi on Wednesday lauded the efforts of each and every…

2 months ago

Waqf Amendment Bill JPC 1 Crore Emails Nishikant Dubey VHP Vinod Bansal Said it Email Jihad | वक्फ बिल पर 1 करोड़ से ज्यादा सुझाव: VHP बोली

Waqf Amendment Bill Email: वक्फ संशोधन बिल पर संयुक्त संसदीय समिति (जेपीसी) को सुझाव के लिए…

2 months ago

Georgia Meloni and Elon Musk date truth behind the viral photos

Meloni And Musk Viral Photos : दुनिया के सबसे अमीर शख्स एलन मस्क ज्यादातर किसी…

2 months ago